Cell migration and invasion
Cell migration, also known as cell crawling, or cell movement, refers to the movement of a cell after receiving a migratory signal or sensing a gradient of certain substances. Cell migration is an alternating process of pseudopodia extension at the cell head, the establishment of new adhesions, and retraction of the cell body tail in a spatiotemporal manner. Cell migration, one of the basic functions of normal cells, is a physiological process of normal growth and development of the organism, and a ubiquitous form of movement of living cells. Cell migration is implicated in processes such as embryonic development, angiogenesis, wound healing, immune responses, inflammatory responses, atherosclerosis, and cancer metastasis.
Cell invasion refers to the ability of cells to migrate from one area to another through the extracellular matrix. Cell invasion is a response of normal and cancer cells to chemical and mechanical stimuli. Before migrating to new areas, the extracellular matrix is degraded by proteases within the cell. Cell invasion often occurs during wound repair, vascularization and inflammatory response as well as abnormal tissue infiltration, tumor cell metastasis, and so on.
A.Cell migration for human skin melanoma cell line A20578
B.Cell invasion for human skin melanoma cell line A20578
Yu, Hong et al. “Propofol suppresses proliferation, invasion, and migration of human melanoma cells via regulating microRNA-137 and fibroblast growth factor 9.” Journal of cellular physiology vol. 234,12 (2019): 23279-23288. doi:10.1002/jcp.28896